Projects (1) developing, characterizing, or improving research models of human health and diseases, (2) developing biology based new approach methodologies (NAMs) applicable to human health and diseases, or (3) improving access to information about or generated from the use of models of human disease. Must: (1) broadly apply to >1 NIH Institutes or Centers’ scientific interests, (2) evaluate diseases and processes that impact multiple organ systems, (3) describe the need for and potential impact of the proposed resources. [Posted 12/5/2025. Expires 9/29/2028.]
Other NIH Funding
Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)
Supports continuation of existing or development of new special colonies of laboratory animals and associated services and other resources such as informatics tools, reagents, cultures, and genetic stocks serving the biomedical research community. Proposed projects should: (1) provide research resources facilitating optimization and enhancement of scientific rigor, transparency, and experimental reproducibility, (2) broadly apply to multiple NIH Institutes or Centers. [Posted 12/4/2025. Expires 1/10/2029.]
Maximizing Investigators’ Research Award (MIRA) (R35 – Clinical Trial Optional)
Allows investigators to: (1) tackle ambitious scientific projects more creatively with more stable funding, (2) be more flexible in following important new research directions, (3) reduce their administrative burden related to grants and dedicate time to research and mentorship. Open to eligible NIGMS-funded investigators and New Investigators proposing research aligned with NIGMS’ scientific mission. Allows renewal applications from all current MIRA grantees. [Posted 12/11/2025. Expires 05/27/2028.]
NIH Exploratory/Developmental Research Project Grant (Parent R21 Basic Experimental Studies with Humans Required)
Supports the early and conceptual stages of exploratory and developmental research projects that may involve considerable risk but may lead to a breakthrough in a particular area or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. [Posted 12/18/2024. Expires 01/08/2028.]
Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required)
Provides a new pathway for ESIs who wish to propose research projects in a new direction for which preliminary data do not exist. Open to a broad range of scientific research relevant to the mission of the participating NIH Institutes and Centers (ICs), notably NIA, NICHD, ORWH. [Posted August 25, 2025. Expires August 26, 2028.]
Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)
Supports research projects by exceptionally promising ESIs with a long-term career interest in pursuing innovative research in genomics. Open to research in all areas relevant to the mission of NHGRI, including genomic sciences, genomic medicine, genomic data science, and ethical, legal, and social implications (ELSI) of genomics. [Posted 12/16/2024. Expires 2/27/2027]
Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional)
Supports exploratory and innovative research projects that fall within the missions of the NINDS and NIMH. Awards will provide support for the early and conceptual stages of projects. [Posted 1/8/2025. Expires 1/8/2028]
Joint NINDS/NIMH Exploratory Neuroscience Research Grant (R21 Clinical Trial Not Allowed)
Supports exploratory and innovative research projects that fall within the missions of the NINDS and NIMH. [Posted 1/8/2025. Expires 1/8/2028]
Interventions on Health and Healthcare Disparities on Non-Communicable and Chronic Diseases in Latin America: Improving Health Outcomes Across the Hemisphere (R01 – Clinical Trial Required)
Supports innovative and interdisciplinary team research focused on clinical, health services, and/or community-based interventions that address health and healthcare disparities related to non-communicable and chronic diseases with the highest disease burden and mortality in Latin America and among U.S. Hispanics/Latinos. [Posted 1/13/2025. Expires 5/8/2027]
Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)
Supports studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, sustainability, scale-up, and spread of evidence-based interventions. [Posted 10/30/2024. Expires 1/8/2028]