Uro-Lit Live

A MONTHLY VIRTUAL DISCUSSION FORUM FEATURING RECENT UROLOGY PUBLICATIONS
Uro-Lit Live is a monthly virtual forum to discuss recent publications in urogenital research with the authors and investigators from the broader urogenital research community. Each forum features a new topic and new authors. Uro-lit Live forums are free to attend and are open to all investigators.
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Uro-Lit Live Articles
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Urobiota analysis and genome-wide association study in pediatric recurrent urinary tract infections and vesicoureteral reflux
Urinary tract infections (UTIs) are the most common severe bacterial infections in young children, often associated with vesicoureteral reflux (VUR). To explore host genetic-microbiota interactions and their clinical implications, we analyzed the…
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Urinary biochemical ecology reveals microbiome-metabolite interactions and metabolic markers of recurrent urinary tract infection
Recurrent urinary tract infections (rUTIs) are a major clinical challenge, and their increasing prevalence underscores the need to define host-microbiome interactions underlying susceptibility. How the urinary microbiota engages with the biochemical environment…
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Compound 48/80 increases bladder compliance by activating MMP-2 and inhibiting TIMP-2
The urinary bladder must remain distensible enough to expand as urine is produced yet strong enough to expel urine without rupture. Disruption in the arrangement of the bladder wall extracellular matrix (ECM)…
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Human bladder organoids model urinary tract infection and bacteriophage therapy
Urinary tract infections (UTIs), primarily caused by uropathogenic Escherichia coli (UPEC), are among the most common antibiotic-resistant infections. Despite this, currently available preclinical UTI models lack the breadth of morphotypic and heterogenous cell populations…
