The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is planning a workshop series, in collaboration with the Innovative Science Accelerator Program (ISAC), on groundbreaking approaches to engineer replacement kidneys. Session 2 – Advancing Uremic Toxin Removal will take place on June 21, 2024 at 1:00 PM ET (12 PM Central | 10 AM Pacific).
The goals for these virtual workshops are to spotlight emerging research, spark innovative ideas, identify synergies between approaches and foster interdisciplinary collaborations, engage in meaningful discussions between researchers and the community and identify tools that can catalyze research and development in this area. Across the sessions, speakers will highlight opportunities to draw inspiration from other species, leverage advances made in engineering other tissues, and discuss novel approaches to replace lost kidney functions.
Register for the webinar HERE.
Purpose
- To assemble a group of creative individuals with diverse expertise to address the growing problem of end-stage renal disease by replacing kidney functions, specifically focused on the challenge of removing uremic toxins (e.g., researchers focusing on the problem of uremic toxin removal; clinicians involved with care of patients kidney disease/failure; engineers, chemists, and microbiologists with unique tools and approaches; and people living with kidney disease/failure).
- To promote the cross-fertilization of ideas of researchers and engineers from disparate scientific fields with unique perspectives and insights to develop transformative solutions and ideas to replace kidney functions beyond dialysis.
Draft Agenda/Outline:
| 1:00 – 1:05 | Introduction (Eric Brunskill, Danny Gossett, Stephen Ash, Mari Winkler, and Hatim Hassan) |
| 1:05 – 1:25 | Plenary Speaker #1 Stephen R. Ash, MD, FACP, HemoCleanse Technologies, LLC and Ash Access Technology: Introduction to uremic toxins and strategies for their removal (15/5QA) |
| 1:25 – 1:40 | Plenary Speaker #2 Mari Winkler, PhD, University of Washington: How effective the removal of uremic toxins from the gut can be (10/5QA) |
| 1:40 – 1:55 | Plenary Speaker #3 Hatim Hassan, MD, PhD, Mayo Clinic “Oxalate and other considerations” (10/5QA) |
| Brief Talks. (10 minute presentations & 3 minute Q/A)
The objectives for the brief talks are to introduce novel concepts, highlight recent technological or research advances, or harness lessons learned from other fields, toward the session goals. The presentations are not exhaustive reviews but are meant to offer a snapshot of the concepts, perhaps through a few illustrative slides. Attendees are encouraged to take a deeper diver into these and other concepts in the breakout discussions. |
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| 1:55 – 2:08 | Christian Bluechel, Nextkidney: Novel sorbents to regenerate spent dialysate |
| 2:08 – 2:21 | Karin Gerritsen, UMC Utrecht: New strategies to remove uremic toxins |
| 2:21 – 2:34 | Tammy Sirich, MD, Stanford University: Removal of Protein-bound uremic toxins (PBUT) |
| 2:34 – 2:47 | Glenda Roberts, University of Washington, Center for Dialysis Innovation: The importance of patients on design teams |
| 2:47 – 2:55 | Break |
| 2:55 – 3:30 | Breakout Group Discussions (30 minutes) |
| 3:30 – 4:00 | Breakout Group Feedback summaries (~30 minutes) |
| 4:00 – 4:05 | Closing (5 minutes) |