Category: Publications

Urinary tract infections (UTIs) are the most common severe bacterial infections in young children, often associated with vesicoureteral reflux (VUR). To explore host genetic-microbiota interactions and their clinical implications, we analyzed the urinary microbiota (urobiota) and conducted genome-wide association studies for bacterial abundance traits in pediatric patients with UTI and VUR from the Randomized Intervention for Children with Vesicoureteral Reflux and Careful Urinary Tract Infection Evaluation cohorts.

Recurrent urinary tract infections (rUTIs) are a major clinical challenge, and their increasing prevalence underscores the need to define host-microbiome interactions underlying susceptibility. How the urinary microbiota engages with the biochemical environment of the urogenital tract is yet to be fully defined.

The urinary bladder must remain distensible enough to expand as urine is produced yet strong enough to expel urine without rupture. Disruption in the arrangement of the bladder wall extracellular matrix (ECM) can lead to alterations in mechanical compliance, disrupting normal function and resulting in bladder dysfunction.

Urinary tract infections (UTIs), primarily caused by uropathogenic Escherichia coli (UPEC), are among the most common antibiotic-resistant infections. Despite this, currently available preclinical UTI models lack the breadth of morphotypic and heterogenous cell populations of the human bladder, impairing the development of novel therapies.

The goal of this committee of the Interstitial Cystitis/Bladder Pain (IC/BPS) Consensus Group was to address the use of patient related outcomes (PROs) in IC/BPS.

Associations between pelvic organ prolapse and overactive bladder exist, yet little is known regarding minimally invasive overactive bladder therapy use among older women following prolapse surgery.

Oxalate, a compound derived from both diet and metabolism, contributes to multiple renal and vascular diseases. Certain gut bacteria degrade oxalate, limiting absorption and promoting secretion.

Kidney stones are increasingly recognized as a systemic disorder with a high global prevalence. However, large proteomics studies are lacking.

Antibiotic-recalcitrant recurrent urinary tract infection (rUTI) is increasingly observed in postmenopausal women. When standard therapies fail, some elect electrofulguration (EF) of areas of chronic cystitis detected on office cystoscopy.

Bothersome lower urinary tract symptoms (LUTS) can negatively affect the quality of life in women, including sexual function. The primary aim of the study was to explore the association between LUTS severity and sexual functioning among women with LUTS.