Development of Novel or Improved Infertility Technologies (R61/R33 Clinical Trial Optional)

The purpose of this NOFO is to support and facilitate multidisciplinary research approaches for the development or improvement of technologies – including drugs, devices, products, or clinical practices – designed to improve fertility outcomes in patients dealing with infertility, particularly in the context of assisted reproductive technologies (ART).  This NOFO aims to position innovative and validated technologies for future clinical development.

[Posted 9/23/25. Expires 11/21/25.]

NIH Blueprint for Neuroscience: Coordination Center for Interoception Research (BPCCIR) (U24, Clinical Trial Not Allowed)

This NOFO aims to foster interactions within the broad community of interoception researchers rather than focusing on disease-specific subdisciplines. Proposed efforts should: 1) establish and maintain a multidisciplinary team of interoception researchers to oversee and guide NBCCIR activities; 2) create and support digital communication platforms to facilitate networking, collaborations, and information dissemination; 3) plan, organize, and host at least one scientific meeting per year that will include NIH-funded interoception researchers, trainees, and other stakeholders; 4) identify challenges and future technological and scientific opportunities for the field of interoception and develop common terminology, data standards, and common data elements; and 5) generate metrics of success and plans to ensure the sustainability of the interoception research community. [Posted 9/2/2025. Due 11/10/2025.]

NIH Exploratory/Developmental Research Project Grant (Parent R21 Basic Experimental Studies with Humans Required)

PA-25-307: The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity is for basic science experimental studies involving humans (per NOT-OD-18-212, “prospective basic science studies involving human participants”). [Posted 12/18/2024. Expires 01/08/2028.]

Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required)

The purpose of the Stephen I. Katz Early Stage Investigator Research Project Grant is to provide a new pathway for Early Stage Investigators (ESIs) who wish to propose research projects in a new direction for which preliminary data do not exist. This notice of funding opportunity (NOFO) is open to a broad range of scientific research relevant to the mission of the participating NIH Institutes and Centers (ICs).
[Posted August 25, 2025. Expires August 26, 2028.]

Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)

Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional) This Notice of Funding Opportunity is intended to identify and support research projects by exceptionally promising Early Stage Investigators with a long-term career interest in pursuing innovative research in genomics. This opportunity is open to research in all areas relevant to the mission of NHGRI, including genomic sciences, genomic medicine, genomic data science, and ethical, legal, and social implications (ELSI) of genomics. [Posted 12/16/2024. Expires 2/27/2027]

Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional)

Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional) The Joint NINDS/NIMH Exploratory Neuroscience Research Grant program supports exploratory and innovative research projects, which fall within the missions of the NINDS and NIMH. Awards will provide support for the early and conceptual stages of projects. [Posted 1/8/2025. Expires 1/8/2028]

Interventions on Health and Healthcare Disparities on Non-Communicable and Chronic Diseases in Latin America: Improving Health Outcomes Across the Hemisphere (R01 – Clinical Trial Required)

Interventions on Health and Healthcare Disparities on Non-Communicable and Chronic Diseases in Latin America: Improving Health Outcomes Across the Hemisphere (R01 – Clinical Trial Required) The purpose of this Notice of Funding Opportunity (NOFO) is to support innovative and interdisciplinary team research focused on clinical, health services, and/or community-based interventions that address health and healthcare disparities related to non-communicable and chronic diseases (NCDs) with the highest disease burden and mortality in Latin America and among U.S. Hispanics/Latinos. [Posted 1/13/2025. Expires 5/8/2027]

Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)

The Stimulating Hematology Investigation: New Endeavors (SHINE) program is intended to promote innovative, high-quality nonmalignant hematology research relevant to the missions of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Aging (NIA), and the National Heart, Lung, and Blood Institute (NHLBI). [Posted 11/06/2024. Expires 1/7/2028]

Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)

The purpose of this Notice of Funding Opportunity (NOFO) is to support studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, sustainability, scale-up, and spread of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies (hereafter referred to as evidence-based interventions). [Posted 10/30/2024. Expires 1/8/2028]