This is not a notice of funding opportunity (NOFO).

The purpose of this topic is to advance scientific understanding of autoimmune disease development, progression, and impact, and to improve health outcomes for those affected.

The NIH encourages research projects that:

• Harness computational tools and collaborative networks to investigate protective and driving factors of pre-clinical autoimmunity, disease inception, and flares in human cohorts. This may include studying the interplay of genetics, immunome, and the exposome across the lifespan.
• Advance diagnostic testing, biomarkers, predictive models, and technologies (e.g., point-of-care testing, imaging, sensors, wearables) for autoimmune diseases.
• Develop novel research models, including New Approach Methodologies (NAMs), that help explore shared mechanisms across co-occurring and discrete autoimmune disorders and the prodromal phase of autoimmunity.,

Participating Institutes and Centers include NIDDK*, NIA, NICHD, NINDS, and NIAID.

*NIDDK may give special consideration to support meritorious applications in this topic area.

Expires February 12, 2028.