This topic is being issued as part of the Make America Healthy Again initiative. This is not a notice of funding opportunity (NOFO).

The NIH’s investments in large-scale clinical consortia, longitudinal cohorts, and repositories have generated high-quality biospecimens and rich, multidimensional datasets spanning clinical, imaging, multi-omics, environmental data, and patient-reported outcomes. The NIH encourages researchers to utilize specific existing research resources in research project grants (RPGs), with the goal of generating new insights into disease mechanisms, prevention, diagnosis, and treatment. Participating institutes include NIDDK and NIA.

Resources of interest from the NIDDK include but are not limited to:

• The NIDDK Central Repository: from clinical trials and clinical research consortia
  • Multimodal data (clinical, imaging, genomic, metabolomic, survey, mHealth/wearables)
  • Biospecimens 
• The Kidney Precision Medicine Project (KPMP) Kidney Tissue Atlas
  • Whole slide images, segmentation masks, multi-omic data, and plasma and urine biomarkers
• NIH repositories that host genomic and multi-omic data from NIDDK studies include:
  • database of Genotypes and Phenotypes (dbGaP)
  • Gene Expression Omnibus (GEO)
  • Metabolomics Workbench

The NIDDK may dedicate funds available to support applications in this topic area depending upon the availability of funds, the number of meritorious applications, and competing priorities. Additionally, the NIDDK may give special consideration to support meritorious applications in this topic area.

Resources of interest from the NIA include (but are not limited to):

• the AgingResearchBiobank
• rodent and nonhuman primate tissue banks
• interventions testing programs
• population-representative, epidemiological, and deeply-phenotyped longitudinal studies.

Expires September 16, 2028.