This is not a notice of funding opportunity (NOFO).

The NIH has identified the use of All of Us biospecimens in research project grants (RPGs) as a research priority area and is encouraging researchers to leverage funding mechanisms offered by participating NIH Institutes, Centers, or Offices (ICOs), such as the NIDDK, NICHD, and NIA, to analyze biospecimens donated by All of Us participants. Researchers who have approval for access to All of Us biospecimens are expected to secure additional funding to support sample processing, data generation and curation, analysis and integration, and return of value to participants. To learn more about expanded biospecimen access, visit the All of Us Research Hub.

The use of All of Us biospecimens in RPG submissions can accelerate research, reduce costs, and provide a clear path to share data with the broader researcher community and for other researchers to build on the work generated from these awards.

Of particular interest are applications that use All of Us biospecimens to support broad-scale biomarker and omics analyses in general populations or broadly informative subpopulations, especially where these approaches may reduce the need for new biospecimen collection.

Potential assay approaches may include, but are not limited to, long-read sequencing, genome-wide methylation profiling, proteomics, metabolomics, immune profiling, and other multiomic analyses derived from these biospecimens as part of a broader scientific project that seeks to:

• Advance understanding of biology, risk, diagnosis, prognosis, or disease stratification;
• Integrate newly generated biospecimen-derived data on the All of Us Researcher Workbench
• Produce datasets of broad utility to the research community; and
• Enhance the long-term value of the All of Us dataset, including returning data to the program.

Expires September 18, 2028.