Up to $12m to support patient-centered comparative clinical effectiveness research (CER) projects. Relevant topic themes include kidney and urologic disease, managing pain, and digital health technologies, though submissions are not limited to these themes.

PCORI strongly encourages applicants to propose individual or cluster randomized controlled trials; however, well-specified natural experiments and well-designed observational studies will also be considered. Strict implementation or dissemination studies will not be considered responsive, nor will studies focused on the development of research methods. Applicants should propose well-justified and validated outcomes that are clinically meaningful and considered important by patients, and that can be impacted by the proposed interventions within the study duration.  Applicants may propose coverage of structured mentorship activities for early- or mid-career investigators, investigators making a career transition to patient-centered CER and/or patient and community partners.

LOI deadline: January 6, 2027, 5 pm ET

LOI decision notification: February 16, 2027

Application deadline: May 4, 2027, 5 pm ET