RFA-AI-27-005: Up to $12m / y in direct costs for 7 years to support a program aiming to design, implement, and manage clinical research that addresses pivotal clinical questions related to antimicrobial resistance (AMR) through a coordinated and integrated Clinical Research Network (CRN). The CRN will comprise four centers: the Scientific Leadership Center (SLC), the Clinical Operations Center (COC), the Laboratory Center (LC), and the Statistics and Data Coordination Center (SDCC). The CRN is anticipated to prioritize clinical research that targets the most significant AMR threats posed by various bacterial and fungal pathogens, encompassing both antibiotic- and antifungal resistant and -susceptible strains. The research will focus on areas where current therapies are insufficient or exacerbate AMR, addressing urgent infections such as healthcare-associated, bloodstream, urinary tract, and respiratory infections.

Application deadline: November 10, 2026