Supports research that integrates engineering and life sciences to solve biomedical problems. May include: methods, models, and enabling tools applied to understand or control living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; or new approaches to the design of systems that include both living and non-living components for eventual medical use. Does not support drug design and delivery, the development of biomedical devices that do not include a living biological component, or the development of animal models of disease. Strongly recommended that PIs contact the program director to avoid the possibility of the proposal being returned without review. [Full proposals accepted anytime]