NSF Division of Molecular and Cellular Biosciences (MCB) Core Programs(NSF 24-539). The program gives high priority to projects that advance mechanistic understanding of the structure, function, and evolution of molecular, sub-cellular, and cellular systems, especially research that aims at quantitative and predictive knowledge of complex behavior and emergent properties. MCB also encourages interdisciplinary research that draws on knowledge from and interfaces with other biological sub-disciplines or other disciplines. This solicitation calls for proposals in research areas supported by the 4 MCB core clusters: (i) structure, dynamics, and function of biomolecules and supra-molecular assemblies, especially under physiological conditions (Molecular Biophysics); (ii) organization, processing, expression, regulation, and evolution of genetic and epigenetic information (Genetic Mechanisms); (iii) cellular structure, properties, and function across broad spatiotemporal scales (Cellular Dynamics and Function); and (iv) systems and/or synthetic biology to study complex interactions through modeling or manipulation or design of living systems at the molecular-to-cellular scale (Systems and Synthetic Biology). Open to all career stages, typical awards last 3-5 yrs, budgets not limited. Rolling deadline.