Up to $750K total costs (including 10% indirects) for 3 years to support research projects addressing fundamental questions of major clinical significance to reproductive medicine.

Applications must fall within one of these 4 priorities areas:

• Research projects involving human gametes  such as ones aiming to understand human egg maturation; determine single sperm variability to evaluate quality and function in clinical IVF; apply what has been learned from animal models to in vitro gametogenesis in the human; evaluate feasibility and safety of gene editing approaches in human gametes.
• Research projects involving human embryos  such as ones attempting to determine single cell (blastomere, trophectoderm, ICM cell) variability (chromosomal, transcriptomic, metabolomic, etc); define in molecular and cell biological terms cell lineages in the early human embryo; develop methodologies for the evaluation of “stressors” and safety of methodologies in the clinical IVF laboratory; investigate the feasibility and safety of gene editing approaches in human embryos.
• Research projects evaluating outcomes  by developing questionnaires and software for the long-term follow-up of children and their parents following fertility treatments. Building on existing databases and registries is strongly encouraged.
• Research projects on access to fertility care by developing metrics to evaluate the needs for access to fertility care in low resourced setting(s) or in underrepresented minorities; determine the cost effectiveness and feasibility of easily implementable approaches for the evaluation of fertility status; develop treatment methodologies for cost effective fertility care.

Must be an independent investigator (faculty of an accredited medical school or university program (public/state or private), research institute or other non-profit or for-profit organization) within the US focusing on research and/or care of patients with reproductive problems. Must have completed research and/or clinical training for at least 3 years prior to application submission.

LOI Deadline: August 24, 2026