Broad Pragmatic Studies PCORI Funding Announcement — Cycle 2 2026
Up to $12m to support patient-centered comparative clinical effectiveness research (CER) projects. Relevant special area of emphasis includes management of urogynecological and pelvic pain, though submissions are not limited to this topic. PCORI strongly encourages applicants to propose individual or cluster randomized controlled trials; however, well-specified natural experiments and well-designed observational studies will also be considered. Strict implementation or dissemination studies will not be considered responsive, nor will studies focused on the development of research methods. Applicants should propose well-justified and validated outcomes that are clinically meaningful and considered important by patients, and that can be impacted by the proposed interventions within the study duration. Applicants may propose coverage of structured mentorship activities for early- or mid-career investigators, investigators making a career transition to patient-centered CER and/or patient and community partners.
LOI deadline: April 28, 2026, 5 pm ET
LOI decision notification: June 2, 2026
Application deadline: Sept. 1, 2026, 5 pm ET