The goal of the Aging Gene Discovery (AGed) Collaborative NSC Pilot Award is to identify new genes and gene networks that control aging and age-associated disease by:
- Performing whole-genome CRISPR-based arrayed genetic screens at the Oklahoma Nathan Shock Center CRISPR Whole-Genome Screening Core using mammalian (human, mouse) cell-based models, that will identify new candidate genes and gene networks controlling aging and age-associated dysfunction/disease;
- Testing genes identified in CRISPR whole-genome screens for their role in aging and/or age-associated dysfunction or disease phenotypes in invertebrate models (C elegans and yeast) at the UW Nathan Shock Center Invertebrate Models of Aging Core;
- Generating a genetically engineered mouse model to further test genes identified in CRISPR whole-genome screens for their role in aging and/or age-associated dysfunction or disease using unique resources of the Jackson Laboratory Nathan Shock Center Animal and Phenotyping Core.
Early-stage investigators focusing on aging and/or geroscience research (the latter as the study of processes linking aging to the etiology of age-associated dysfunction and disease) or senior investigators initiating new research programs in aging/geroscience research are encouraged to apply. Awards range from $38,000 to $75,000 depending on factors such as project complexity and reagent costs.
Consultation with leaders of the above cores to discuss the project and whether it is appropriate for this multi-NSC pilot program is required for application consideration. Application Deadline: February 15 , 2026. Pilot award funding would be for one year (May 2026 – end of April 2027). Please submit applications and inquires to: uwhalo@uw.edu