Engineering Next-Generation Human Nervous System Microphysiological Systems (R21 Clinical Trials Not Allowed). This Notice of Funding Opportunity (NOFO) encourages research grant applications directed toward developing next-generation human cell-derived microphysiological systems (MPS) and related assays that replicate complex nervous system architectures and physiology with improved fidelity over current capabilities. Supported projects will be expected to enable future studies of complex nervous system development, function and aging in healthy and disease states. The R21 grant mechanism is intended to encourage exploratory/developmental research by providing support for the early and conceptual stages of project development. High risk/high reward projects that lack preliminary data may be most appropriate for this NOFO. Applicants with preliminary data may instead wish to apply to the companion R01 NOFO, which is identified above under the “Companion Funding Opportunity” heading.
Posted on 11/6/2024. Expires on 1/8/2026. Due dates are 5/16/2025 and 10/16/2025.